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ᾷ Ԩº ҧä¨ŵ

ᾷ Ԩº ҧä¨ŵ

ᾷ Ԩº ҧä¨ŵ

ӹѡҹԨ觪ҵ (Ǫ.) зǧش֡ Էʵ Ԩйѵ (.) ʹѺʹععԨç ͧ : ҧä¨ŵ: ä˵طҧѹءСѡäŵ ʵҨᾷ ๵ Ф ᾷʵ ŧóԷ ʵҨᾷ § ó 繷֡ ֡˵طҧѹءСѡäŵº餹͹ѺªԵ

.ѵ ͧ ӹ¡ӹѡҹԨ觪ҵ  Ǫ. зǧش֡ Էʵ Ԩйѵ պҷӤѭ㹡عʹѺʹعԨйѵӤѭͧ ֧äغѵԴ ͧҡʶҹóѨغѹѭҷԴ鹡Ѻ ԴҡѭɰԨ ѧ Ǵ ֧Դä·繻ѭҵآҾСôçվ “äŵ”äº˵˹觷ԴѺءȷءѧѧռªԵҡäŵҧͧ Ǫ.繶֧Ӥѭͧᾷ䢻ѭ˵آͧäŵ ֧ʹѺʹععԨ ᾷʵ ŧóԷ Թç ʵҨ ᾷ ๵ ֡͡˵طҧѹءСѡäŵ¡ùͧҧ ҵʹǷҧ㹡ѡǧ÷ҧᾷͻªѧǹͧȪҵԵ

ʵҨ ᾷ ๵ ˹çԨ Դ ҡ֡ “äŵ” ˵طӤѭͤԴԢͧ öٺմʹ§ǹҧ ੾ͧ ͧҴ͡ਹҨʴҡêѡ §״ҴԴԤ¹͹ ¡ Դѡй͹ѺʹԷ ҨԴ㹼·آҾç ҡá͹ҹ͹һԴ 辺ªԵ㹵͹觢ͧաѹ ªԵзѹѹѭҳ͹ҡ͹ ͡ҡԴҡ鹼Դѧ ͡ҡѧҡŵ¢з͹Ѻѡ͹ Ҩ㹢еԵШѹ ҡ蹪ǧ ҡٺʵѺ ªԵҡäŵǹ˭辺㹷ءҤͧ ੾ҤҹҤ˹羺ҧ㹼˭ԧ ٧ ѵԢͧ㹺ؤŢͧͺǷ觪Ҿѹء˵ѡӤѭҧ˹觢ͧԴä

ѡԨ ӡä鹤֡ “ҧä¨ŵ” 觤鹾 Ѩ·Դ “äŵ (Brugada syndrome)” Ҿѹءͧäŵ㹼 239 СǺӹǹ 478 Ընʹʾѹءͧ (whole genome sequencing) ӹǹҳ 15% դǢͧѺá¾ѹչ SCN5A »ҳ˹ ¾ѹ쪹Դ p.R965C ѧ鹨֧ջѨ ԴäҼǹ˭ä˵بҡԴäҧѹءդѺ͹äẺչ (polygenic) 觡ä鹾öҾѲ㹡֡ԨŴ§ҡԴä

駹 ҡä鹾ǡâͧԴäҡöʹʾѹءͧ ͧѺҡ֡Ԩ¾չǢͧ SCN5A, SCN10A HEY2 觡ä鹾˵ءԴäöõʹǹӤѭ͡кǹ÷ҧᾷͧ äŵ Brugada syndrome öѡ ѺԹԨ·١ͧ ¼§٧Ѻͧеءѵѵ (implantable cardioverter-defibrillator) šѡä¡è¨شԴ㨴¤Է (RF ablation) ºѺѡҵðҹ㹻Ѩغѹ šѡѧѺõԴ㹢й繡ùǷҧѡä͹Ҥ¡þѲԴª٧شҡ֡ʾѹءͧ鹹Ƿҧͧѡäŵ·ҨԴѺءзءѧͻªͻȪҵ

 
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